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EClinicalMedicine 29-30:100642

The "effective dose" in a 250-gram rat does not translate directly to a dose for an 80-kilogram human

Glucose deprivation reduces the PPP-mediated NADPH generation, making it impossible to reduce insoluble cystine imported via xCT to a more soluble cysteine, thereby inducing disulfide stress (i.e., cystine-dependent toxicity) and leading to rapid cell death [48] [Figure 3B]

Barba, C

Plant-derived remedies hold medicinal value and are pivotal in research due to their rich content of phytochemicals such as terpenoids, glycosides, alkaloids, polyphenolics, and steroids (Fuhrman et al ., 2004
