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[DOI] [PubMed] [Google Scholar] 42.Wang D., Zhai J
Inhibition of GPX4 activity leads to the accumulation of lipid peroxides, which triggers ferroptosis

however, these findings highlight one of the complexities of using antioxidant therapies, as increased GPx1 activity was correlated with enhanced ERK1/2 activation when analyzing memory, whereas increased GPx1 correlated with a decrease in ERK1/2 activation in the hypoxic preconditioning study, presumably due to the loss of hydrogen peroxide-mediated ERK1/2 activation

198 At the transcriptional level, p16 and p21 are the most commonly used markers to identify senescent cells

10.1093/humupd/dmw039 18 CheY.YuJ.LiY
