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Vitamin B12 has a core made of another molecule (i.e., cobalt)

Hexachlorophene was an extensively used bisphenol that was mainly applied as an antiseptic agent in personal care products (Marzulli and Bruch, 1981) until concerns over its neurotoxicity led to it being banned in the US in 1970s (Heidler and Halden, 2009)

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Major Reclassification : This detailed, stepwise procedure applies to applications that break new ground, such as a new type of medicine or condition being considered for a classification change