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The heart, kidney, and brain as target organs in hypertension
In cross-sectional studies, low circulating IGF-I levels were found to be associated with angiographically documented coronary artery disease [275] and may predict fatal ischemic heart disease [272], a significantly increased risk of ischemic stroke and congestive heart failure in elderly patients [276,277], as well as a worse prognosis of recovery after an acute myocardial infarction [278]
Growth Hormone and Sex Steroid Administration in Healthy Aged Women and Men: A Randomized Controlled Trial
Furthermore, individuals with diabetes were found to have lower circulating ALA levels, supporting ALAs positive impact in the management of DPN [206,207]
Subsequently, transmembrane serine protease type 2 (TMPRSS2), expressed in host cells, facilitates the virus entry by proteolytic cleaving [10]
