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Hyperproliferation is the main driver of metabolomic changes in psoriasis lesional skin
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It is involved in cell migration, matrix construction, protease production, tension regulation and defense response, and actively contributes to wound healing and maintenance of skin homeostasis by enhancing cell adhesion, diffusion, proliferation and signal transduction mechanisms (Gardeazabal and Izeta, 2024
It is believed that depression is caused by disturbed levels of neurotransmitters, mainly serotonin, norepinephrine, and dopamine
