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Gu research team confirmed in both in vivo and in vitro experiments of SCIRI that Sal can reduce the abnormal generation of ROS through antioxidant stress, lower the abnormal opening of mPTP, alleviate mitochondrial structural damage, and inhibit the release of Cyt C, blocking the activation of the mitochondrial-dependent apoptotic pathway (Gu et al., 2020)

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Panahi, Y., Khalili, N., Sahebi, E., Namazi, S., Reiner, , Majeed, M., Sahebkar, A.: Curcuminoids modify lipid profile in type 2 diabetes mellitus: a randomized controlled trial