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Biosynthesis of deoxyribonucleotides Ribonucleotide reductases (RNRs) are essential enzymes in all living cells, responsible for reduction of ribonucleotides to deoxyribonucleotides (EC 1.17.4.1) (Figure 8)

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And other concurrent issues can mask progress: if your sleep is poor, your iron is low, your thyroid is off, or your testosterone is suboptimal, fixing B12 alone won't solve everything