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Notably, the deletion of the C-terminal domain completely impairs the PC synthesis activity of the enzyme in the presence of Zn 2+ and partially inactivates PC synthesis in the Cd- or Hg-containing reactions [53, 55]

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doi: 10.3389/fimmu.2019.01033 87 ZhuoWJiaLSongNLuXADingYWangXet al

Sirtuin 2 (SIRT2)-P53 signaling pathway The SIRT2-p53 pathway exerts neuroprotective effects by modulating GPX4 and SCL7A11, inhibiting the occurrence of ferroptosis (100)

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