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By directly downregulating SIRT1, miR-34a leads to increased synthesis of inflammatory cytokines, including IL-6, TNF-, IL-1, and IL 8, and oxidative stress proteins, including MCP-1, vascular cell adhesion protein 1 (VCAM1), and MDA, and decreased levels of the anti-inflammatory cytokine IL-10 [297, 303]
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The brain is particularly susceptible to oxidative stress due to its high oxygen consumption, lipid content, and relatively low levels of antioxidant enzymes compared to other tissues
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It requires a well functioning immune system
