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For all longitudinal analyses, we used generalized estimating equations to adjust standard errors to account for the correlation of observations within individuals, with the working covariance structure being first-order autoregressive for the models where time was a continuous variable and independence for the models where time was a categorical variable

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doi: 10.3389/fphar.2022.929262 Received 26 April 2022 Accepted 30 June 2022 Published 12 August 2022 Volume 13 - 2022 Edited by Christoph Reinhardt, Johannes Gutenberg University Mainz, Germany Reviewed by Zeneng Wang, Cleveland Clinic, United States Saravanan Subramaniam, Boston University, United States Updates Copyright 2022 Zixin, Lulu, Xiangchang, Qing, Binjie, Chunyang, Tai and Dongsheng