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The gene expression of plasma membrane glutamate transporter SLC1A2 (EAAT2) declined with aging in mouse endothelial cells, pericytes, microglia, and neurons (Ximerakis et al., 2019), including some hypothalamic GABAergic neurons (Ximerakis et al., 2019), whereas SLC1A2 expression increased with aging in some tanycytes (Jin et al., 2025)

Because breast cancer immunotherapy is in the ascendant, understanding the metabolic dependence between infiltrating immune cells and cancer is an important direction for future research

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