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The other significantly elevated miRNAs included miR-192-3p, miR-27a, miR-335-5p, and miR-34a, all of which have previously been linked to liver fat accumulation, insulin resistance, and inflammation

doi: 10.1097/IN9.0000000000000030

Thyroid-stimulating immunoglobulin, when it bonds with healthy thyroid cells, causes the thyroid to produce excessive hormones

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In conjugates of the invention wherein the agent comprises a poly- or oligonucleotide, the pharmaceutically acceptable carrier preferably is a lipoplex system comprising at least one of cationic lipids or amphoteric lipids (as detailed inWO2002/066012), or a polyplex system comprising at least one of poly-L-Lysine, poly-L-ornithine, polyethyleneimine, and polyamidoamine