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a , e by two-tailed unpaired t -test
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Daily administration of 4 mg ARA 290 administered subcutaneously was well tolerated without any evident adverse effects
On the other hand, the activated caspase-1 cleaves interleukin (IL)-18 and IL-1 precursors to form and release active IL-18 and IL-1 extracellularly, thereby recruiting inflammatory cells and aggravating the inflammatory response (Schroder and Tschopp, 2010
