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29,30 Despite these benefits, the trials assessing the efficacy of LOLA suffer from several biases related to inadequate blinding, incomplete data, selective reporting, and pharmaceutical funding

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Efficacy and safety of liraglutide versus placebo as add-on to glucose-lowering therapy in patients with type 2 diabetes and moderate renal impairment (LIRA-RENAL): a randomized clinical trial

The protein levels of pyruvate dehydrogenase kinase 1 (PDHK1), a negative regulator of PDH activity through phosphorylation, are increased during reprogramming, which decreases conversion of pyruvate into acetyl-CoA and hence, favoring the generation of lactate ( via alternative splicing ( At later stages of reprogramming, core pluripotency factors Oct4, Sox2, Nanog, c-Myc, are directly involved in the maintenance of aerobic glycolysis

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