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Jalewa et al., 2017
J Neurosci Res 84:578586 Lipton AJ, Johnson MA, Macdonald T, Lieberman MW, Gozal D, Gaston B (2001) S-nitrosothiols signal the ventilatory response to hypoxia
: Antioxidants and detoxifier
To address the critical limitations of conventional PROTACs, particularly the Hook effect-induced nonlinear pharmacokinetics and narrow therapeutic window
The highest binding affinity for GPx4 with a docking score of 7.6kcal/mol and greater ligand exposure was exhibited by Lapatinib, which bonded with the enzyme at ASP165 and TYR169 residues
