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Blocking FRAAs (bFRAAs) interfere with folate binding and receptor-mediated endocytosis, lowering CSF 5-MTHF despite adequate systemic folate and leading to a functional brain-specific folate deficiency

Nature 479 (7372), 223227

doi: 10.37077/25200860.2024.37.1.21 16 AlkofideH.AlhammadA

Clinical trials in mitochondrial disorders, an update

or, when R 6a , R 6b , R 7a and R 7b are independently halogen, the halogen is independently fluorine, chlorine or bromine
