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Chambers et al, 1999a, 1999b

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Int J Funct Nutr

Further, studies on a comprehensive understanding of the mechanisms or pathways that regulate the reversible nature of the corresponding modifications should be undertaken

Preclinical studies have shown that co-targeting ferroptosis and pyroptosis (e.g., GPX4 inhibitor + GSDMD activator) can overcome compensatory resistance by engaging complementary cell death mechanisms, amplifying DAMP release, and enhancing T cell infiltration (60, 181)