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Briefly, l-norcarnitine (3-hydroxy-4-dimethylaminobutyric acid) was prepared from l-carnitine (Chem Impex International) with thiophenol (Sigma-Aldrich) in N , N -dimethylaminoethanol (Sigma-Aldrich) and then was converted to its sodium salt with sodium hydroxide by the method of Colucci et al

The study for healthy subject cohort had been registered in ClinicalTrials.gov as NCT02838732

Questo composto si forma nell'intestino quando alcuni batteri metabolizzano la L-carnitina e viene successivamente assorbito ed elaborato dal fegato

The arena used was the open field, with mice habituated to the empty area for 5 min the day before the NOR test