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Moreover, GERD amelioration might require 10% BW loss, which is hardly achievable and sustainable without pharmacotherapy 108

A 2023 safety trial (n=200) confirmed no hepatotoxicity or allergy beyond 1% (Babu et al., 2023)

(2002) and Hellemans et al

Loperamide-loaded and insulin-modified HSA presented an increase in size because of the existence of insulin agglomeration on the surface, demonstrating the successful preparation of such insulin-targeting nanoparticles using NHS-PEG-MAL5000 crosslinker
International journal of pharmaceutics, 583 , 119340
