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In humans, it has been observed that VIC may prevent the onset of osteoarthritis, but also vice versa, with high concentrations of VIC being associated with an increased risk of developing osteoarthritis [117] and VIC did not prevent damage to cartilage structure [117,118]

Genome-wide studies have shown that circadian sampling in rodents, non-human primates, and human tissues indicates that over 80% of FDA-approved drug targets exhibit daily rhythms (Zhang et al., 2014

By helping the body restore antioxidant balance, this therapy supports brain vitality, reduces inflammation, and protects against oxidative stressrelated damage.

This approach is explored with small molecule drug erastin (named after eradicator of RAS and ST-expressing cells) identified to efficiently kill human tumor cells without affecting their isogenic normal cell counterparts [160]

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