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KEGG annotation and enrichment analysis A KEGG Compound database ( was used to annotate the identified metabolites, which were then mapped to KEGG Pathway database ( After determining which pathways had significantly regulated metabolites, MSEA (metabolite sets enrichment analysis) was performed

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30 Our findings demonstrated that the total ROS level was elevated in H1299-shCPT1A cells treated with cisplatin, compared to untreated cells (Fig