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These modifications can change the conformation of proteins, resulting in dysfunction and the accumulation of misfolded proteins in the cytoplasm, which are implicated in cellular aging, apoptosis, and necrosis 89

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Fisetin is abundantly found as a dietary flavonoid found in various fruits (strawberries, apples, mangoes, persimmons, kiwis, and grapes), vegetables (tomatoes, onions, and cucumbers), nuts, and wine [145]