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Garzon R, Liu S, Fabbri M, Liu Z, Heaphy CE, Callegari E, Schwind S, Pang J, Yu J, Muthusamy N, Havelange V, Volinia S, Blum W, Rush LJ, Perrotti D, Andreeff M , Bloomfield CD, Byrd JC, Chan K, Wu LC, Croce CM, Marcucci G

Arginase pathway in macrophages not only permits parasites to diminish the production of free radicals but also enhances the capacity of parasites to grow by the production of polyamines ( in vitro together with the demonstration that, in the pilot clinical trial described here, the NAC treatment induces a higher production of sCD40L and that this production negatively correlates with IL-10 levelssuggests that the effect of NAC is associated with a better regulation of the innate and adaptive immune responses

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They have shown broad antimicrobial (bactericidal, fungicidal and virucidal) effects against a number of pathogenic and MDR microorganisms and thus have potential to overcome microbial drug resistance [21, 142, 144]