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Although DPN did not differ between the two groups, this complication of diabetes is often regarded as a sleep disruptor [11, 32]

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Prostate cancer cells co-cultured with adipocytes increase expression of IL1- to stimulate adipocyte lipolysis in a vicious positive feedback loop that decreases prostate cancer cell sensitivity to docetaxel and upregulates prostaglandin E2 (PGE2) synthesis in adipocytes, a prostate cancer pro-survival signal (212)

In our study, FOXO4-DRI was found to effectively promote apoptosis in senescent cells by blocking the FOXO4-P53 interaction and facilitating P53 phosphorylation
