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Front Med (Lausanne) (2022) 9:760852
The elimination of senescent astrocytes using senolytics led to marked inhibition of glioma growth and prolonged survival in mice ( Targeting SASP also might strengthen immune responses
E.GijonM.KennedyP
Further mechanistic studies revealed that JuB treatment upregulated total Nrf2 levels, promoted its nuclear translocation, increased the expression of HO-1 and NQO-1, and inhibited the activation of the STING pathway induced by APAP
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