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This extraordinary potency arises from the combination of the D-phenylalanine substitution at position 7, which confers enzymatic resistance and enhanced receptor binding geometry, the Nle substitution at position 4 that prevents methionine oxidation, and the cyclic lactam constraint that pre-organizes the pharmacophore into the bioactive conformation

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Intriguingly, the cancer-associated expression of CT2 is observed in tissues that generally do not express this transporter

In Vitro Characterization of Variable Porosity Wound Dressing With Anti-Scar Properties