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Moreover, microglial cells (MGCs), a primary source of GLP-1 secretion in the brain, have been implicated in early neurodegeneration in diabetic mouse models (144), highlighting the GLP-1-mediated impact on cognitive function

J Endocrinol Invest 21 : 506511 Rikken B et al

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For example, curcumin is notoriously poorly bioavailable: in animal studies, only nanogramlevel concentrations of curcumin appear in plasma after oral dosing, and in humans even doses as high as 8 g orally can result in undetectable or extremely low plasma levels [36]

LC-MS identification was carried out by electrospray on HPLC Waters Alliance 2690