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However, regular intramuscular injections are a significant strain on resources (both time and financial) and are inconvenient for patients, so a trial of oral replacement therapy may be suitable in some cases

Bibcode:1984Natur.307..131N
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Importantly, metformin does not completely block vitamin B12 absorption
On the one hand, some clinical evidence supports that GLP-1RA can improve body composition and muscle function