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Amyloid-Beta and Phosphorylated Tau Accumulations Cause Abnormalities at Synapses of Alzheimers Disease Neurons

Conclusion The pathogenesis of PD originates from complex interactions between genetic susceptibility and environmental factors, ultimately converging into four core pathological events: -syn misfolding, mitochondrial dysfunction, OS, and neuroinflammation

As a very simple way of looking at it, when your body is constantly being bombarded with glucose and insulin as a result of poor diet and lifestyle factors, your body eventually becomes desensitized to insulin, which starts you down the path to insulin resistance

Even then, this decision is never rushed and is taken only after detailed counselling and shared decision-making