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It binds plasma proteins more tightly and is retained far longer, which is why a single dose holds therapeutic levels for roughly eight to twelve weeks and supports a maintenance interval of two to three months

These symptoms may indicate advanced deficiency requiring immediate treatment, particularly in pregnancy, infancy, or following nitrous oxide exposure

Repeated injections into the same spot cause scar tissue and lipohypertrophy, both of which reduce B12 absorption over time

This is why FDA-approved options exist for chronic weight management (for people who meet criteria)
