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In the mouse experiment of this cohort study, the investigators found that knocking out Keap1 resulted in the expression of Nrf2 target genes (such as GSH and NQO1), which supplemented the consumption of GSH in the oxidative stress response (Mohs et al., 2021)
Notes : Important considerations, such as administration route (SubQ, IM, Nasal), stacking advice, or unique side effects

However, this association was not replicated in a larger Japanese cohort [93]

Miller PF
