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Cholesterol in the central nervous system (CNS) comes, almost entirely, from endogenous synthesis as the circulating cholesterol is unable to cross the bloodbrain barrier (BBB)

Cell 111 : 607610 Zheng M, Aslund F and Storz G (1998) Activation of the OxyR transcription factor by reversible disulfide bond formation

[DOI] [PMC free article] [PubMed] [Google Scholar] 124.Messina J.P., Lawrence D.A

Furthermore, comparing Prdx Km for H 2 O 2 with that of GPx and catalase exceeding even the millimolar range [180] suggests that the role of Prdx is rather as a sensor of H 2 O 2 [178] than oxidative stress condition reversal

I., Shumaev, K