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No official human dosing standard exists, so doses should be set with a physician

Djimde A, Doumbo OK, Cortese JF, Kayentao K, Doumbo S, et al

In the same way, pejorative endpoint such as treatment failure, or negative long-term outcomes such as hospitalization or even colectomy will be prompter to occur among patients starting with less effective first-line advance therapy

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It is critical to note that the safety profile for injectable or systemic use is far less established due to a lack of human research
