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The sulfur-containing thiol group in cysteines side chain is key to its properties, enabling the formation of disulfide bridges between two peptide chains (as with insulin) or loop formation within a single chain, impacting the final protein structure

RSL3 (S8155) and erastin (S7242) were purchased from Selleckchem

"Sentiment toward these guys is as negative as it's ever been," Emily Field, head of European pharmaceuticals research at Barclays, told CNBC over the phone Wednesday

[DOI] [PubMed] [Google Scholar] Mustelin T, Vang T, Bottini N

Binda C, Hublek F, Li M, Herzig Y, Sterling J, Edmondson DE, Mattevi A (2004) Crystal structures of monoamine oxidase B in complex with four inhibitors of the N-propargylaminoindan class