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IGF-1 activates the Akt pathway, which is a downstream activator of mTOR, both of which are the master regulators of cellular growth and inhibitors of programmed cell death in the body
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These data suggested that the protection of 5-HT might be partially due to the inhibition of apoptosis of hepatic cells mainly by suppression of Bcl-2 proteins phosphorylation
J Neurochem 96:12891300 Rebrin I, Sohal RS (2008) Pro-oxidant shift in glutathione redox state during aging
The practical goal is not perfection
