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In colorectal cancer (CRC) cell lines, dusigitumab neutralized IGF-2 and induced significant tumor growth inhibition in mouse models that overexpressed IGF-2, a finding that supports evaluation of dusigitumab in CRC patients whose tumors overexpress IGF-2 [128]
KumarSSinghSKWangXRupBGillD.Coupling of aggregation and immunogenicity in biotherapeutics: T- and B-cell immune epitopes may contain aggregation-prone regions

Blood transfusions are required whenever there is an appreciable decrease in RBCs due to hemolysis or blood loss

K.DicksL

doi:10.1128/MCB.21.10.3534-3546.2001
