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HMGB1 regulates erastin-induced ferroptosis via RAS-JNK/p38 signaling in HL-60/NRASQ61L cells

Ruze R, Chen Y, Xu R, Song J, Yin X, Wang C, et al

Glutathione is the most abundant antioxidant in the body
[DOI] [PMC free article] [PubMed] [Google Scholar] 158.Sun, S

However, in the p38 KD + LPS group, although there was partial restoration of Nrf2 pathway activity relative to the LPS group, AKK failed to further enhance the expression levels of Nrf2, HO-1, or NQO1 under p38-deficient conditions
