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J Clin Endocrinol Metab 86:15041510

And the anecdotal reports from dog owners while not a substitute for clinical trials are consistent enough to take seriously

Stay hydrated, follow a balanced diet rich in fruits and vegetables, and avoid excessive sun exposure to sustain your skin brightening and anti-aging results

The most compelling research endpoints involve mortality and disease incidence tracked over years, as demonstrated in the long-term follow-up studies showing reduced mortality in treated groups

Science (1991) 254(5033):8215.10.1126/science.1948064 42 WellsJA