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3.5.2 Inhibition of inflammatory factors As adipose tissue expands, both enlarged adipocytes and resident immune cells undergo a transformation in their behavior: they shift from releasing primarily anti-inflammatory and protective substances to generating substantial amounts of inflammatory adipokines and other cytokines that promote inflammation, impacting both the local area and the entire body (Figure 6)

doi: 10.1371/JOURNAL.PONE.0179586 277 YangY.KarakhanovaS.HartwigW.DHaeseJ

1, July 2007, pp

doi:10.1007/s10545-008-0841-x 10.Pourahmad J, Eskandari M, Kaghazi A, Shaki F, Shahraki J, Fard J