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Every oral remedy runs into the same wall: the GI tract

10.1186/s40478-015-0200-8 Acta Neuropathol

SamuelBSShaitoAMotoikeTReyFEBackhedFManchesterJKet al
Impaired integrin (5) /(1) -mediated hepatocyte growth factor release by stellate cells of the aged liver

This is one of the main reasons the two are paired together rather than administered separately
