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Mishima and Pinkus [9] introduced the term melanoacanthoma to describe this benign condition although prior to this designation, Bloch [10] described a similar case in 1927 as "non-naevoid melanoepithelioma Type 1." Melanoepithelioma Type 2 is the term used to describe ordinary pigmented seborrhoeic keratosis

PMID: 20545686

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Among the upregulated genes, several Th1-associated markers were identified, such as Ifng , Tbx21 , Il18r1 , Irf1 , which are enriched in Gene Ontology (GO) pathways related to Th1 cell differentiation or activation, and IFN- response (Fig
