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It is also produced by tissues outside the liver where it acts locally in a paracrine fashion and is believed to play an important autocrine role in cancer [4]
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Int J Hepatol 2012:582790 Cederbaum AI (2010) Role of CYP2E1 in ethanol-induced oxidant stress, fatty liver and hepatotoxicity

Cutting edge: Nrf2 regulates neutrophil recruitment and accumulation in skin during contact hypersensitivity
