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Tamoxifen increases the levels of ceramide, JNK phosphorylation and markers of apoptosis We next determined the effects of tamoxifen on caspase-3 activation, which is known to cleave poly (ADP-ribose) polymerase (PARP) and other proteins leading to apoptosis

Nutrients 14:1220 [DOI] [PMC free article] [PubMed] [Google Scholar] Plaitakis A, Shashidharan P (2000) Glutamate transport and metabolism in dopaminergic neurons of substantia Nigra: implications for the pathogenesis of Parkinsons disease

This was linked to elevated activities of catalase and superoxide dismutase (SOD)

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Indeed, all studies finding interactions between ASA and folate had high intakes of ASA (for instance, 650 mg ASA every 4 h for 3 days [177]) (Figure 2)