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doi: 10.1007/s10142-023-01055-7

Although TZDs can increase body weight, weight gain mostly occurs in subcutaneous fat, while visceral fat, which is closely related to metabolic disorders, does not increase or even decreases

[DOI] [PMC free article] [PubMed] [Google Scholar] 62.Pullen N., Zhang N., Alonso A.D., Penfield S

Moreover, c-Myc loss impairs polyamine synthesis, due to both upstream defects in glutaminolysis and decreased expression of polyamine biosynthesis genes

It boosts cellular energy and repair mechanisms, reducing the appearance of aging signs and improving skin texture and resilience
