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10.3724/SP.J.1142.2010.40491 39 KimS

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described M2 macrophage polarization through STAT6-mediated reciprocal epigenetic alterations in histone H3 lysine4 and histone H3 lysine27 methylation, which resulted in transcriptional activation of particular M2 manufacturing genes (176)

In a phase IIB, double-blind, randomized, placebo-controlled trial we are currently testing atorvastatin to reduce inflammation after TB treatment completion (StatinTB, ClinicalTrials.gov identifier: NCT04147286)