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Overexpression of MGMT results in decreased response to alkylating agents such as TMZ, as evidenced by the significantly improved survival outcomes in the MGMT promotor methylated group (Median PFS 19 mo vs

However, Gclc KO mice still lost substantial weight while on an HFD, although to a lesser extent than normal chow (Fig

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doi: 10.1186/s12929-015-0189-0 24
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