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Biomed Eng Clin
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5 HF Validation for Product Design Changes within the Clinical Timeline Design changes to combination products may require an additional HF validation test, particularly if changes occur after clinical studies or a prior validation test
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In mouse models, two independent groups reported that Tert and Terc KO mice do not present spontaneous lung fibrosis and that Terc deficiency does not affect bleomycin-induced lung fibrosis (Liu et al., 2007
