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however, the only statistically significant difference was between the LD control group and both groups switched from WD to LD, regardless of their treatment (Supplementary Fig
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These include individuals with chronic low levels, confirmed by a blood test, people with conditions that impair absorption (like celiac or Crohns disease), older adults, people with darker skin, and those who spend little time in the sun

By activating both incretin pathways, tirzepatide enhances insulin secretion in a glucose-dependent manner, suppresses glucagon release, delays gastric emptying, and reduces appetite through central nervous system effects
